Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats

Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats

OBJECTIVE The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in ...

Cardioprotective Effect of Bioflavonoids against Isoproterenol Induced Cardiotoxicity in Rats

The present study was undertaken to explore the cardioprotective potential of bioflavonoids against isoproterenol induced cardiotoxicity in rats. Cardiotoxicity was induced by isoproterenol (85mg/kg body weight) in animals. Blood biochemical, hematological parameters, urinalysis and histopathological studies were carried to assess the cardio protective effect. Isoproterenol administration induc...

Cardioprotective Effect of Naringin against Doxorubicin Induced Cardiomyopathy in Rats

Cardioprotective effect of Crataegus aronia syn. Azarolus (L) Aqueous Extract Against Doxorubicin-Induced Cardiotoxicity and Heart Failure in Wistar Rats

We examined whether Crataegus aronia (C. aronia) can ameliorate Doxirubicin (DOX) induced cardiotoxicity in rats. Six groups of Wistar rats were divided as: Group I: a control group (administered saline); Group II: administered aqueous extract of C. aronia alone; Group III: administered DOX alone; Group IV: administered concomitant doses of both DOX and C. aronia; Group V: administered DOX firs...

Cardioprotective Effect of Cornus Mas Fruit Extract against Carbon Tetrachloride Induced-Cardiotoxicity in Albino Rats

In the present study, cardioprotective effect of Cornus mas fruits extract (CMFE) was evaluated in a rat model having acute cardiotoxicity, induced by single dose of carbon tetrachloride (CCl4) (1ml/kg i.p.). Pre and post treatment of C. mas fruit extract (300 and 700mg/kg) in CCl4-treated rats significantly decreased the increased levels of serum lactate dehydrogenase, serum creatine kinase an...